2019 Ryan White HIV/AIDS Program CLINICAL CONFERENCE
Clinical and demographic characteristics of PLWH with Type 1 vs. Type 2 MI Characteristic T1MI* T2MI Pvalue N=362 56% N=288 44%
Male
293
81% 19%
207
72% 28% 16% 37% 34%
Sex
0.006
Female
69 32
81 47
<40
9%
40-49 50-59 60-69
152 125
42% 35% 12%
106
Age
99 22 14 65
0.01
43 10
8% 5%
≥70
3%
White
171
47%
23%
African-American 156
43%
202
70%
Race/Ethnicity
<0.001
Hispanic
19 16
5% 4%
14
5% 2%
Other/unknown Heterosexual
7
101 166
28% 46% 22% 27% 20% 54% 60% 21% 19% 60% 13% 17% 5%
93 75
32% 26% 37% 45% 19% 35% 70% 16% 14% 44% 17% 20% 18% 5%
HIVTransmissionRisk Factor
MSM
<0.001
IDU
78 17 96 71
107
Other/unknown
13
0-200
130
CD4countclosest toevent (cells/µl)
201-350
56
<0.001
>350 0-200
194 215
102 201
CD4cellcountnadir (cells/µl)
201-350
77 69
47 40
0.03
>350 <400
217
127
400-10,000
47 63 34
49 59 53
HIV-1RNAclosest toevent
<0.001
10,000-100,000
>100,000
9%
Slide19of 43FromHMCrane, MD inNewOrleans, LA, December 4-7, 2019, Ryan WhiteHIV/AIDS ProgramCLINICAL CONFERENCE, IAS USA.
Cardiovascular disease risk factors among PLWH with Type 1 vs. Type 2 MI
T2MI
Pvalue
T1MI*
Characteristic
56%
N=288
44%
N=362
15
19
0.2
HDL (mg/dL)
40
42
43
40
<0.001
LDL (mg/dL)
108
87
52
60
<0.001
Non-HDL (mg/dL)
149
125
Lipid Levelsmean (SD)
TotalCholesterol (mg/dL)
190
54
167
63
<0.001
182
272
0.4
Triglycerides (mg/dL)
227
208
No
244
67%
232
81% <0.001
StatinUse
Yes
118
33%
56
19%
No
125
35%
136
47% 0.005
Smoking
Former
56
15%
36
13%
Current
181
50%
116
40%
BodyMassIndexmean (SD)
BMI
26
5
24
6
0.001
Risk Scoremean (SD)
Framingham CHD
10
8
8
7
<0.001
Slide20of 43FromHMCrane, MD inNewOrleans, LA, December 4-7, 2019, Ryan WhiteHIV/AIDS ProgramCLINICAL CONFERENCE, IAS USA.
Rates of Type 1 and Type 2 MI per 1000 person-years of follow-up
CROI,2019
Slide21of 43FromHMCrane, MD inNewOrleans, LA, December 4-7, 2019, Ryan WhiteHIV/AIDS ProgramCLINICAL CONFERENCE, IAS USA.
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