2019 Ryan White HIV/AIDS Program CLINICAL CONFERENCE

Roadmap ▪ Why do we care? ▫ HIV-infected vs. uninfected, incidence

▪ MI types in HIV ▫ Universal MI definition ▫ CNICS MI adjudication ▫ Type 1 vs. Type 2 MIs ▪ Why increased risk ▪ Other CVD ▪ What do we do? ▫ Risk scores ▪ Summary

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Why do we care about CVD and HIV

▪ CVD risk is significantly higher among those with HIV

▪ The impact of CVD is substantial in terms of both morbidity and mortality

▪ The impact will likely continue to increase with the aging of the population of those with HIV

▪ Traditional risk factors play an important role in CVD and HIV

▪ Non-traditional risk factors play an important role in CVD and HIV

▪ Does understanding the role of inflammation and HIV factors teach us about HIV itself, other comorbidities of HIV, or CVD?

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CVD risk and impact among PLWH by country

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PLWH twice as likely to develop CVD Global burden of HIV-associated CVD has tripled over the last two decades

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Shah et al.Circulation, 2018

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