2019 Ryan White HIV/AIDS Program CLINICAL CONFERENCE

Other potential contributors

 Co-morbidities – infectious and non-infectious

Psychiatric illness



Medication effects



Recreational drug use



Others…



Slide 19of46FromVValcour,MD,PhDatNewOrleans,LA,December4-7,2019,RyanWhiteHIV/AIDSProgramCLINICALCONFERENCE, IAS  USA.

Distinguishing Alzheimer’s disease from HIV-related cognitive impairment

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Increased risk of symptomatic dementia associated with co- morbidity

100

90

Insert Figure on added burden of vascular disease on hiv HIV + CVD + AD

80

70

?

60

50

Theoretical increasedrisk associated withcomorbiditysuchasCVD

40

30 impairment

Ageassociated populationrisk for dementia

20

10

Prevalence of symptomatic

0

55

60

65

70

75

80

85

90

Existing data

Age

Slide 21of46FromVValcour,MD,PhDatNewOrleans,LA,December4-7,2019,RyanWhiteHIV/AIDSProgramCLINICALCONFERENCE, IAS  USA.