2019 Ryan White HIV/AIDS Program CLINICAL CONFERENCE

Early ART can Greatly Reduce T Cell Activation

Jain et al, JID, 2013

See also: Burdo, JID, 2011; Vinikoor, CROI 2012, Abstract #554

Slide37of43FromSGianellaWeibel,MD atNewOrleans,LA,December4-7,2019,RyanWhiteHIV/AIDSProgramCLINICAL CONFERENCE, IAS  USA.

Statins Decrease Monocyte Activation in Treated HIV Infection (SATURN-HIV Trial)

Slide38of43FromSGianellaWeibel,MD atNewOrleans,LA,December4-7,2019,RyanWhiteHIV/AIDSProgramCLINICAL CONFERENCE, IAS  USA. Funderburg, 2014 CID

Diet and Exercise

• High fat or carbohydrate meal ↑ inflammation (Deopurkar, Diabetes Care, 2010).

• Diet-induced weight loss ↓ inflammation in elderly ( Nicklas, Am J Clin Nutr, 2004)

• RCTs of exercise in elderly have been shown to:

– Decrease inflammation (Nicklas, JAm Ger Soc, 2008)

– Increase functional status (McMurdo, Geriatrics, 1992)

– Decreases insulin resistance (Diabetes Care, 2002)

– Improve cognitive function (Muscari, Int J Ger Psych, 2010)

• Studies in HIV?

Slide39of43FromSGianellaWeibel,MD atNewOrleans,LA,December4-7,2019,RyanWhiteHIV/AIDSProgramCLINICAL CONFERENCE, IAS  USA.