2019 Ryan White HIV/AIDS Program CLINICAL CONFERENCE

Microbial Translocation

Damaged GI tract during HIV infection

Healthy GI tract

J.BrenchleyandD.Douek

Slide31of43FromSGianellaWeibel,MD atNewOrleans,LA,December4-7,2019,RyanWhiteHIV/AIDSProgramCLINICAL CONFERENCE, IAS  USA.

Microbial Translocation Decreases with ART but Persists for Years

Jiang et al, JID, 2009 (also Marchetti, AIDS, 2008)

Slide32of43FromSGianellaWeibel,MD atNewOrleans,LA,December4-7,2019,RyanWhiteHIV/AIDSProgramCLINICAL CONFERENCE, IAS  USA.

Microbial Translocation is Associated with Inflammation

Perez Santiago 2013,AIDS

Slide33of43FromSGianellaWeibel,MD atNewOrleans,LA,December4-7,2019,RyanWhiteHIV/AIDSProgramCLINICAL CONFERENCE, IAS  USA.